{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "$id": "schema:Drug",
  "title": "Drug",
  "description": "A chemical or biologic substance, used as a medical therapy, that has a physiological effect on an organism. Here the term drug is used interchangeably with the term medicine although clinical knowledge makes a clear difference between them.",
  "type": "object",
  "allOf": [
    {
      "description": "Any offered product or service. For example: a pair of shoes; a concert ticket; the rental of a car; a haircut; or an episode of a TV show streamed online.",
      "$ref": "schema:Product"
    },
    {
      "description": "Any matter of defined composition that has discrete existence, whose origin may be biological, mineral or chemical.",
      "$ref": "schema:Substance"
    }
  ],
  "properties": {
    "activeIngredient": {
      "description": "An active ingredient, typically chemical compounds and/or biologic substances.",
      "oneOf": [
        { "type": "string" },
        { "type": "array", "items": { "type": "string" } }
      ]
    },
    "administrationRoute": {
      "description": "A route by which this drug may be administered, e.g. 'oral'.",
      "oneOf": [
        { "type": "string" },
        { "type": "array", "items": { "type": "string" } }
      ]
    },
    "alcoholWarning": {
      "description": "Any precaution, guidance, contraindication, etc. related to consumption of alcohol while taking this drug.",
      "type": "string"
    },
    "availableStrength": {
      "description": "An available dosage strength for the drug.",
      "oneOf": [
        { "$ref": "schema:DrugStrength" },
        { "type": "array", "items": { "$ref": "schema:DrugStrength" } }
      ]
    },
    "breastfeedingWarning": {
      "description": "Any precaution, guidance, contraindication, etc. related to this drug's use by breastfeeding mothers.",
      "type": "string"
    },
    "clincalPharmacology": {
      "description": "Description of the absorption and elimination of drugs, including their concentration (pharmacokinetics, pK) and biological effects (pharmacodynamics, pD).",
      "type": "string"
    },
    "clinicalPharmacology": {
      "description": "Description of the absorption and elimination of drugs, including their concentration (pharmacokinetics, pK) and biological effects (pharmacodynamics, pD).",
      "oneOf": [
        { "type": "string" },
        { "type": "array", "items": { "type": "string" } }
      ]
    },
    "dosageForm": {
      "description": "A dosage form in which this drug/supplement is available, e.g. 'tablet', 'suspension', 'injection'.",
      "oneOf": [
        { "type": "string" },
        { "type": "array", "items": { "type": "string" } }
      ]
    },
    "doseSchedule": {
      "description": "A dosing schedule for the drug for a given population, either observed, recommended, or maximum dose based on the type used.",
      "oneOf": [
        { "$ref": "schema:DoseSchedule" },
        { "type": "array", "items": { "$ref": "schema:DoseSchedule" } }
      ]
    },
    "drugClass": {
      "description": "The class of drug this belongs to (e.g., statins).",
      "$ref": "schema:DrugClass"
    },
    "drugUnit": {
      "description": "The unit in which the drug is measured, e.g. '5 mg tablet'.",
      "type": "string"
    },
    "foodWarning": {
      "description": "Any precaution, guidance, contraindication, etc. related to consumption of specific foods while taking this drug.",
      "type": "string"
    },
    "includedInHealthInsurancePlan": {
      "description": "The insurance plans that cover this drug.",
      "$ref": "schema:HealthInsurancePlan"
    },
    "interactingDrug": {
      "description": "Another drug that is known to interact with this drug in a way that impacts the effect of this drug or causes a risk to the patient. Note: disease interactions are typically captured as contraindications.",
      "oneOf": [
        { "$ref": "schema:Drug" },
        { "type": "array", "items": { "$ref": "schema:Drug" } }
      ]
    },
    "isAvailableGenerically": {
      "description": "True if the drug is available in a generic form (regardless of name).",
      "type": "boolean"
    },
    "isProprietary": {
      "description": "True if this item's name is a proprietary/brand name (vs. generic name).",
      "type": "boolean"
    },
    "labelDetails": {
      "description": "Link to the drug's label details.",
      "type": "string",
      "format": "uri"
    },
    "legalStatus": {
      "description": "The drug or supplement's legal status, including any controlled substance schedules that apply.",
      "anyOf": [
        { "type": "string" },
        { "$ref": "schema:DrugLegalStatus" },
        { "$ref": "schema:MedicalEnumeration" }
      ]
    },
    "maximumIntake": {
      "description": "Recommended intake of this supplement for a given population as defined by a specific recommending authority.",
      "$ref": "schema:MaximumDoseSchedule"
    },
    "mechanismOfAction": {
      "description": "The specific biochemical interaction through which this drug or supplement produces its pharmacological effect.",
      "type": "string"
    },
    "nonProprietaryName": {
      "description": "The generic name of this drug or supplement.",
      "type": "string"
    },
    "overdosage": {
      "description": "Any information related to overdose on a drug, including signs or symptoms, treatments, contact information for emergency response.",
      "type": "string"
    },
    "pregnancyCategory": {
      "description": "Pregnancy category of this drug.",
      "$ref": "schema:DrugPregnancyCategory"
    },
    "pregnancyWarning": {
      "description": "Any precaution, guidance, contraindication, etc. related to this drug's use during pregnancy.",
      "type": "string"
    },
    "prescribingInfo": {
      "description": "Link to prescribing information for the drug.",
      "type": "string",
      "format": "uri"
    },
    "prescriptionStatus": {
      "description": "Indicates the status of drug prescription, e.g. local catalogs classifications or whether the drug is available by prescription or over-the-counter, etc.",
      "anyOf": [
        { "type": "string" },
        { "$ref": "schema:DrugPrescriptionStatus" }
      ]
    },
    "proprietaryName": {
      "description": "Proprietary name given to the diet plan, typically by its originator or creator.",
      "oneOf": [
        { "type": "string" },
        { "type": "array", "items": { "type": "string" } }
      ]
    },
    "relatedDrug": {
      "description": "Any other drug related to this one, for example commonly-prescribed alternatives.",
      "oneOf": [
        { "$ref": "schema:Drug" },
        { "type": "array", "items": { "$ref": "schema:Drug" } }
      ]
    },
    "rxcui": {
      "description": "The RxCUI drug identifier from RXNORM.",
      "type": "string"
    },
    "warning": {
      "description": "Any FDA or other warnings about the drug (text or URL).",
      "anyOf": [{ "type": "string", "format": "uri" }, { "type": "string" }]
    }
  }
}